Regulatory Toxicology and Chemistry

Chemical-specific toxicological criteria are frequently critical factors affecting remediation, restoration, or compliance costs for products, sites, or waste streams. We understand the importance of toxicological criteria in regulatory decision-making and work with our clients and appropriate regulatory agencies to ensure that the criteria used are based on the best available toxicological information and appropriate dose-response modeling.

Our experience in this area includes:

  • Development of cancer potency factors and non-cancer reference doses for chemicals with environmental or workplace exposure significance
  • Application of causation criteria to human and environmental epidemiologic studies
  • Development of toxicological criteria for compounds subject to regulation under California Proposition 65 and other state waste site and toxics programs
  • Implementation of field and laboratory ecotoxicological programs including toxicity testing and biological surveys
  • Derivation of ecotoxicological criteria that have been accepted for use at numerous waste sites in the US and abroad
  • Application of physiologically-based pharmacokinetic (PBPK) modeling, structure activity analyses relationships (SAR), and biochemical mechanistic models to develop toxicological criteria
  • Validation and quality assurance of analytical data used in developing toxicological criteria, to ensure that data are of the highest quality and reliability
  • Advanced chemical and microbiological data validation for monitoring and other data sets
  • Development of analytical techniques for unique compounds